Exogenous Heparan Sulfate Enhances the TGF-β3-Induced Chondrogenesis in Human Mesenchymal Stem Cells by Activating TGF-β/Smad Signaling
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چکیده
منابع مشابه
Periosteum as a source of mesenchymal stem cells: the effects of TGF-β3 on chondrogenesis
INTRODUCTION Numerous experimental efforts have been undertaken to induce the healing of lesions within articular cartilage by re-establishing competent repair tissue. Adult mesenchymal stem cells have attracted attention as a source of cells for cartilage tissue engineering. The purpose of this study was to investigate chondrogenesis employing periosteal mesenchymal cells. METHODS Periosteum...
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Transforming growth factor-β (TGF-β) is a critical regulator of osteogenic differentiation and the platelet-derived growth factor (PDGF) is a chemoattractant or mitogen of osteogenic mesenchymal cells. However, the combined effects of these regulators on the osteogenic differentiation of mesenchymal cells remains unknown. In this study, we investigated the effects of TGF-β and/or PDGF on the os...
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This study investigated the effect of mechanical load on human mesenchymal stem cell (hMSC) differentiation under different exogenous transforming growth factor-beta1 (TGF-beta(1)) concentrations (0, 1 or 10 ng/ml).The role of the TGF-beta signalling pathway in this process was also studied. Human MSCs were seeded into fibrin-biodegradable polyurethane scaffolds at a cell density of 5 x 10(6) c...
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Objective Adult stem cells which are derived from different tissues, with their unique abilities to self-renew and differentiate into various phenotypes have the potential for cell therapy and tissue engineering. Human adipose tissue is an appropriate source of mesenchymal stem cells with wide differentiation potential for tissue engineering research. In this study isolated stem cells from hum...
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Introduction Transforming growth factor beta (TGF-β) superfamily members play diverse roles in cartilage development and maintenance. TGF-β not only up-regulates a number of molecules associated with prechondrogenic condensation, it also up-regulates chondrogenic gene expression through several signaling pathways. Moreover, TGF-β has been reported to inhibit osteoblast differentiation by repres...
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ژورنال
عنوان ژورنال: Stem Cells International
سال: 2016
ISSN: 1687-966X,1687-9678
DOI: 10.1155/2016/1520136